In IVT, accumulating pyrophosphate (PPi) inhibits T7 and other RNA polymerases. Inorganic pyrophosphatase hydrolyzes PPi to phosphate, preventing product inhibition and sustaining transcription for higher, cleaner mRNA yields at standard reaction conditions. Maximize IVT yield by removing PPi product inhibition. Improve full‑length purity and reduce truncated RNA. Simple spike‑in; no buffer changes to your mix. Cost‑efficient: more mRNA per run saves template and NTPs.

• Maximize IVT yield by removing PPi product inhibition
• Improve full‑length purity and reduce truncated RNA
• Simple spike‑in; no buffer changes to your mix
• Cost‑efficient: more mRNA per run saves template and NTPs

T4 RNA Ligase II (also called T4 RNA Ligase 2) joins 3'-OH RNA to 5'-phosphorylated oligos within duplex contexts, reducing adapter dimers and artifacts. It produces cleaner small RNA libraries and supports dsRNA nick sealing and RNA circularization at various scales.

• Duplex-guided ligation minimizes adapter dimers
• Creates purer small RNA libraries and profiles
• Facilitates dsRNA nick sealing and circularization
• Suitable for both pilot and high-throughput workflows

T7 RNA Polymerase is an enzyme that enables the transcription of RNA from DNA templates. It is an essential tool for various in vitro RNA synthesis applications, offering exceptional specificity and fidelity. This engineered enzyme is manufactured for high purity and is free from contaminating nucleases and DNA, ensuring reliable and consistent performance for your research.

• Synthesizes RNA with high yield and purity for reliable results
• Shows high specificity for T7 promoters, ensuring precise transcription
• Supports diverse applications, including mRNA and CRISPR guide RNA synthesis