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As scientists around the world are rising to the challenge to innovate and devise new approaches to tackle the COVID-19 pandemic, we are continuing as a leader in genome engineering and the life sciences to contribute to ongoing scientific research in pursuit of new solutions to detect SARS-CoV-2, the novel coronavirus that causes COVID-19, prevent infection and treat the disease.
We have been inspired by how rapidly academic and non-profit institutions, the biopharma industry, and scientific pioneers have mobilized to develop new diagnostics, therapeutics, and vaccines, with CRISPR and other advanced technologies paving the way. The speed at which the scientific community is moving is extraordinary, and we are committed to continuing to help accelerate that research – both COVID-19 focused and beyond.
The health of our employees and their families, our customers, and our community is our top priority.
Providing New COVID-19 Genome Engineering Tools to Accelerate COVID-19 Research and Development
Synthego is committed to providing invaluable reagents and services to scientists working to quickly develop COVID-19 diagnostics, therapeutics, and vaccines. Furthermore, our most recent innovations are designed to bolster researchers’ ability to study molecular targets in order to develop diagnostics and therapeutics for SARS-CoV-2 coronavirus strains.
Rapid detection of individuals infected with the novel coronavirus is essential to isolating them and managing appropriate healthcare responses. Researchers are using the reagents that we mass-produce to develop the next generation of SARS-CoV-2 diagnostic tests and future treatments against COVID-19 and other deadly coronavirus strains, and we are continuing to support the life sciences community without disruption.
Fighting infectious diseases and developing new treatments requires an understanding of how a pathogen operates at the interface with the host. Building on recently published data on SARS-CoV-2 protein interactions with human cells, our integrated and industrialized genome engineering factories have rapidly translated this information into effective research tools for studying these interactions. With the potential to combine these research tools with approaches for therapeutic discovery such as high throughput compound screening or drug repurposing, we are prepared to partner with researchers and institutions that are investigating these and other novel therapeutic approaches for the treatment of COVID-19.
Our six new COVID-19 specific collaboration tools are designed to enhance the speed and effectiveness of the development of COVID-19 diagnostics and treatments. Depending on the focus and approach of individual projects, researchers can utilize multiple new genome engineering tools from Synthego, which include the following:
- Bioinformatically designed custom Cas13 guide RNA collections that can be used for individual or multiple gene knockouts to develop diagnostics for SARS-CoV-2, among other applications.
- Algorithmically-designed, multi-arrayed CRISPR sgRNA gene knockout libraries targeting 330 human genes that interact with SARS-CoV-2 proteins. These libraries can be used to investigate the molecular mechanisms of the novel coronavirus to identify drug combinations of enhanced efficacy, as demonstrated in the recently published data.
We hope that our tools and resources will ultimately lead to improved solutions for the current COVID-19 pandemic as well as future pandemics. We are currently fast-tracking all collaborations, inquiries, orders, and shipments related to COVID-19 research and development efforts. Inquiries can be submitted here.
Building for the Future
Although COVID-19 is deservedly taking center stage with biopharma research and development initiatives at this time, scientific innovation and research and development in human biology continue to be a critical need in all areas of medicine.
As part of our commitment to helping researchers pursue new solutions, we have a virtual meeting assessment tool where they can connect directly with one of our genome engineering experts to help identify ways that CRISPR methods may be able to quickly and efficiently answer their complex questions.
We believe the unprecedented innovation that is taking place in response to the COVID-19 pandemic today will provide a foundation for improving human health tomorrow. The speed of the scientific response is representative of a paradigm-shifting movement in the life sciences -- one in which the convergence of multiple technologies, the speed of information flow, and the rapid programmability and agility of technologies like CRISPR will fundamentally change our approach to research and development. Once the public health crisis subsides and all researchers return to their labs, the need for transformative tools and technologies will be greater than ever. With our uncompromised focus on driving toward the intersection of biology and technology, we will be prepared to meet that need and continue to advance and support the leading edge of research and development for scientists around the world.
